Question

1. Look up the structure of naproxen on google image search. Draw the structure below and indicate the acidic proton by circling it. What would the conjugate base of naproxen look like? 2. On another sheet of paper, draw a mechanism for the protonation of... a. water b. methanol c. formaldehyde d. triethylamine 3. On another sheet of paper, draw the mechanism for the deprotonation of... a. methane b. the SH of cysteine C. ammonia d. the OH of butanoic acid 4. Go to Wikipedia and look up the Pauling electronegativity values for the following atoms: co-B- 5. Which is the more polar bond, C-S, C-O or C-B? Explain why using electronegativity values. 6. This compound is called butyllithium Considering the electronegativity of C and Li, draw a reasonable resonance form of the compound that takes into account this very polar, almost ionic bond. 7. Do a google search on the "WHO Model List of Essential Medicines Find a drug (maybe find a small-ish one), explain its use, and then draw its structure below. Highlight and label each of the functional groups.

Answer 1

-но Naproxen ConJugat base et Naproxen' Но (water) H-0- H (proton) ( protanated wates) но-сн, memanod не не Formaldehyde H. Taienylamine Deprotanation is the of HO from Subttance process Removing но CHy methane -H- HS Но OH Nithy cysteine -не NH3 Anmonia + HO но Bufanojc auid

Li =0.98 O = 3.44 B= 2.04 C-0 Bond is MOre polar because electrone gativity difference is highest ie 0.89 Li Amine functional group ketamine (HN Carbony! funchionl group Cketone) sedative for phylically painful proceduves Use- in Emergency departments.