Question

3. Complete the following reaction: OH Ts-Cl COCH pyridine


could you show the mechanism of this reaction?

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Answer #1

Drawn below is the mechanism of the above shown transformation. The first step is converting -OH to a good leaving group -OTs. This step is does not affect the chiral center. The second step is SN2 type nucleophilic substitution reaction wherein, CH3O- acts as nulceophile and attacks the carbon with the leaving group from backside to form product with inversion of configuration.

CH2O Ts Ts OH O-H Ts --CI pyridine 、OCH 3 -CI -TSO SN2 reaction

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could you show the mechanism of this reaction? 3. Complete the following reaction: OH Ts-Cl COCH...
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