Question

Question 1: Fully label - with names or descriptions, NOT values -the reaction coordinate diagram of an enzyme-catalyzed (continuous line) vs. uncatalyzed reaction (dashed line). THEN do the following calculations... a) What is the value of ΔGo, for the reaction? b) Is the reaction spontaneous in the direction written (left to right)? c) What is the value of AG for the catalyzed reaction? d) What is the value of ΔG# for the uncatalyzed reaction? e) Calculate the rate enhancement for this reaction. 4 3.5 2.5 1.5 0.5 Energy kJ/mol -1 1.5 -2 Reaction Coordinate

Answer 1

1. DELTA G (free energy) is the change in energy.

= G (FINAL)-G(INITIAL)

= -5 -0

= -5 KJ/MOL

B. SINCE THE FREE ENERGY CHANGE IS NEGATIVE, THEREFORE, THE REACTION IS SPONTANEOUS.

C. FREE ENERGY CHANGE FOR CATALYZED REACTION IS:

G (FINAL)- G (INITIAL)

= -5 -(0)

= -5 KJ/MOL

D.

FREE ENERGY CHANGE FOR UNCATALYZED REACTION IS:

G (FINAL)- G (INITIAL)

= -5 -(0)

= -5 KJ/MOL