Question

A.Calculate the Kc value for the A-protein binding reaction.

B.Calculate the Kc value for the B-protein binding reaction.

C.Assuming that the drug that binds more strongly will be more effective, which drug is the better choice for further research?A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a proteirn involved in cancer. The drug molecules bind the complex. The protein concentration in aqueous introduced into the protein solution at an initial concentration of 2.00 × 10-6 M. Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00 × 10-6M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00 × 10-6M, and the drug B solution has a B- protein complex concentration of 1.40 × 10-6M.

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Answer #1

a) drug A +protein drugA -protein 1.00x10-5 (1.00x105) 1 2x10 1.56x10-5 E (2x109-x) (1.56x10-*-x sincexis nown 1.00x10 SO E (

b) drug B + protein > drugB - protein 1 2x10-5 1.56x10-5 140x105 E (2x10 -x) (1.56x10-*-x (1.00x10*) sin cexis nown 1.40 x10

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