Question

Choose to put a red blood cell in a hypotonic, hypertonic, or isotonic solution, what is the effect on the RBC? Why is tonicity important in clinical practice?

Answer 1

Arst Red Blood celle Hypotonic solution Hypotone solution R a solution that contain Low concentration of solute compared high amount of water When red blood cells are placed in hypotonit solution environment the water will entes the cell and call swell, subsequently RBCs will bloat up and may explode or get ruptured. Red blood cells in typertonie seketion Hypertonic solution & a solution which contain more quantity of NaCl as compared to that withis RBCs. When red blood cells are placed in hypertonie Sokation, water inside the cells will move out due to process of osmosis into surrounding environment. This will cause RBCs to shrink Teacher's Sign.:

Peege Red Blood cells in Botonic solution Page 1 Isotone solution Å the solution that have equal solute concentration across semipermeable membrane When red blood cells are placed in Botonie solution it means that the solite concentration inside RBCs and outside environment is equall. There will be equilibrium inside and outside the cell and cell will be stable. solution Hypotonie Hypertonic Isotonie Effect on RBC shape swell, burst shrink No change in RBC shape

Page 3 Ans 2 Importance of practice of tonicity in clinical toni In clinical practice, pharmaceutical preparations are administered to patients. These preparations when given by parental route must be Fofonic, Isotonicity preements body from Diminution of volume from extracellular fluids • Diminution of volume from plasma • Swelling of cells • Salt depletion sotonicity § important for For optha me preparations where lack of sotonicity leads to irritation. For parentral preparations a where tonicity dzference may cause cell lysis and inflammalim at site of infection.