Question

6. Drugs often contain chiral centers. When that is the case, it can be critical to make them chiral in a useful way so that they have the desired biological effect. Two examples below illustrate this. With your developing expertise, you should be able to identify the chiral centers and apply the appropriate Rand S nomenclature to the levo- and dextro-rotatory forms of the compounds below. HECO nihon (+)-ethambutol used to treat tuberculosis levomethorphan - a potent oplod analgesic N-CHydor OCH, Но, (-) ethambutol causes blindness dextromethorphan - a over-the-counter cough suppressant (Hint: the N is not chiral) HEC-N

Answer 1

The answer is given in the attachment ...

) ethambuto TH9 YenNOH. HO 2ta tu Hor? SŠ (-) ethambutol F7 2iH → (RR) Leavomeshophan Dextromethophan SOCHE for each chiral carbon- o mark is done. The priority 69 6 9 should go for R-s Nomendeature. ② or @ it in back Orule . S or @ if in back o rule ④ clockwise ? o Opposite to B Anhelockwisel o