Question

Amino acids are useful building blocks for peptide synthesis. However, due to several reactive sites, protecting groups are used to direct regioselective synthesis. Below is the structure of an amino acid with a protecting group. H2N COOH Identify the protecting group. Which reagent was used to install this protecting group? Which reagent is used to remove this protecting group? Fmoc Benzyl chloroformate Boc 9-Fluorenylmethyl chloroformate amide 0 O O O TFA Piperidine DCC H2, Pd/C acetal Di-tert-butyl dicarbonate Acetic anhydride Cbz or Z

Answer 1

Answer:-

The protecting group : fmoc

The reagent used to install this protecting group is : 9-Fluorenylmethyl chloroformate.

The reagent used to remove this protecting group (deprotection) is : piperidine (base).

The fmoc (or 9-fluoroenylmethyloxycarbonyl) group is widely in the protection of amino acids during solid-phase peptide synthesis. It is stable to acidic conditions. It is resistant to HBr in organic solvents and trifluoroacetic acid (TFA). Fmoc protected amines are readily deprotected by using a base.

Emoc group и не о сооно

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