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Drug A has an ED50kVKtJbR+AAJSZtX6aMsPAAAAAElFTkSuQmCC of 5.1 mg and an LD50W7nGL8sMmxLdeftVuBbCQYPLnEie0ecDJQvePjg7 of 49.9 mg, while Drug B has an ED50kVKtJbR+AAJSZtX6aMsPAAAAAElFTkSuQmCC of 3.5 mg and an LD50W7nGL8sMmxLdeftVuBbCQYPLnEie0ecDJQvePjg7 of 36.1 mg. Determine the therapeutic index (TI) for each drug. Which is safer? Why? (There is no graph or image for this question)

8. Drug A has an ED50 of 5.1 mg and an LD50 of 49.9 mg, while Drug B has an ED50 of 3.5 mg and an LD50 of 36.1 mg. Determine

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Answer #1

The therapeutic index (TI)of a drug is the ratio of the lethal dose (LD) to the effective dose (ED). High TI means safer the drug is.

TI = (LD50) / (ED50)

For drug A,

TIA = 49.9 / 5.1 = 9.8

For drug B,

TIB = 36.1 / 3.5 = 10.3

Drug B is more safer. It means in case of B it causes less toxic effect and more therapeutic effect compare to drug A.

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