Question

8. (8 points) in the two schemes below. provide the appropriate reagents) to protect the functional group indicated underneath the first arrow. Then provide the structure of the protected substrate in the 2nd box and the final product in the 3 box. Reagent(s)? Protected substrate Deprotected final product Substrate OH 1. LICH3 2. HF or TBAF CH2Cl2 (Protect the alcohol: you may use the acronym or the line-angle structure) Reagent(s)? Protected substrate Deprotected final product Substrate 1. NaH; THE OH 2. CH3l; THE 3. H30: H20 (excess) (Protect the aldehyde)

In the two schemes below, provide the appropriate reagent(s) to protect the functional group indicated underneath the first arrow. Then provide the structure of the protected substrate in box 2 and the final product in box 3.

Answer 1

TMSC, Pyr, CHELIN 0°c G OH 11 orms/11 Lich (2) HF or TBAR Chall = Tusce 3 OM mu HU(9) ( NaH THE () Cin 2. Tu Bº Ho exceny