Question

Question The malonic ester synthesis has been used countless times to make bioactive molecules. One example is the synthesis of barbiturates. Your answer O a. = OEt Ob. Barbiturates are sedative-hypnotic drugs, which can have many effects ranging from sedation to anesthesia, and even death by acting as central nervous system depressants. Barbiturates are commonly prescribed medications, but are also for several non-therapeutic purposes (often illegally). = Et One particularly famous barbiturate is sodium thiopental, which has been used in psychiatry, lethal injections, and in so- called 'truth serums'. OC. = OEt Following the general scheme shown, predict the structure of the dialkylated product formed in the malonic ester synthesis of this notorious compound. malonic ester synthesis (two alkylations) malinate i i Dialkylated product CNS Depressants analgesics sedatives Sodium thiopental "Truth Serum" 3-4 billion doses prescribed per year

Answer 1

Here we alkylake it 0 start two from, diethyl malonate and ty times - 0 NaOE+ À i Lar -D6601 타 Br (1st alkylated Prodent) (1st alkylat o Navet IN47Nnnnnn 타싸와 Answer-6 and alterated Product Dialkylated Product The m general mechanism of alliglation og i Naott p oet Deprotonation – Naser R BV oet lot proton audic &- proton e ůpet Eto- 2Uwo allylated Compound