Question

3. Assign the chiral carbons in the following drug molecules as either Ror S. Please write your answers in the boxes provided. HNT NH O levetiracetam antiepileptic metaprolol antihypertensive duloxetine antidepressant HOONEN HO-PLONAN NH, 0 HA tenofovir (Gilead) anti-HIV/AIDS sitagliptin (Merck) oral antihyperglycemic n 4. Draw the structure in line-angle representation for (2R, 4R)-2-chloro-4-ethylheptane:

Answer 1

3 R can and s configuration be assigned as- to me following moneules Lerretiraletram anhepilectic 'S configuration configuration Metaprolon Antihypertensive 9 wloxetine Arisidepressant R configuration But nowest priority 'H' at front side .: 's' configuration

MO HO 'R condiguration Tensfarin C critendo Anh H2N-ALOS s Sitaclippin ( Merck) oral and hyperglycemic romsymonhon, but lowest priority 's' ut Pront siele a configuration 'R' compoquration

99 The structure line angle of the CRR, 4R)-2-innoro-h-ehylheptane representation form is as below in (2014R)-2-moro-h-ehylhephane