Chemists are able to kill cancer cells by adding an adamantyl group to a drug that...
Chemists are able to kill cancer cells by adding an adamantyl group to a drug that binds cancer-promoting proteins.
a) How does the large greasy adamantyl group effect the surface of the protein? What does it mimic?
b) What other proteins or cellular systems will respond to this “sign” on the protein surface?
Homework Answers
a) adamantyl group act as a lipophilic bullets. It is interact with lipophilic zone of the surface protein.
b) it known that it bind to DNA and regulate P53 gene as well. It influence P53 indipendent apoptotic pathway by ROS singal.
please see this review The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives.
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