4) How does the regulation of ribonucleotide reductase work to ensure that there are similar amounts...
4) How does the regulation of ribonucleotide reductase work to ensure that there are similar amounts of all four of the dNTP’s? Why is it important that there be equal quantities of each of the dNTP’s?
Homework Answers
Q. How does the regulation of ribonucleotide reductase work to ensure that there are similar amounts of all four of the dNTP’s?
Ans: The ribonucleotides is converted into deoxyribonucleotides with the help of Ribonucleotide reductase.
This reaction is very important with respect to DNA biosynthesis, and also repair.
The Ribonucleotide reductase enzyme is essential for reduction of all the four ribonucleotides.
It reduces them by regulating the binding between effector and distal allosteric site.
Q. Why is it important that there be equal quantities of each of the dNTP’s?
Ans: It is very important to have equal equal quantities of each dNTP's, because the inaccuracy in the concentration of only one dNTP also increases the misincorporation level abruptly.
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