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Caffeine and ibuprofen in a pain reliever tablet were separated and quantified by liquid chromatography. A...

Caffeine and ibuprofen in a pain reliever tablet were separated and quantified by liquid chromatography. A 1.065 g

tablet was dissolved in 1.000 L water. A 50uL portion was injected by syringe into the instrument. The separations

column was 300 mm long, 6 mm diameter, and the flow rate was 1.2 mL/min. A good chromatograph was observed with

well resolved bands. What size column and flow rate should be used to obtain a similar separation from a 1.0 mL portion

of the same sample?

science   chemistry   
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Answer #1

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