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27) Histidine has pKas of 1.82, 9.17, and 6.00 for its carboxyl, amino, and R-groups, respectively. What is the charge of Histidine at pH 7.5? A) -3 B) -1 C)o D) +1 E) +2

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Answer #1

For carboxyl group pka is 1.82, since pH is 7.5, so carboxyl group will act as in acidic medium that is COOH

For amino group pka is 9.17, since pH is 7.5, so amino group will act as in basic medium that is NH2

For R groups pka is 6.00, since pH is 7.5, so R group will act as in acidic medium, but it will not have any charge.

So, net charge is zero

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