Question

=o NaOH -CH₃ + H ya EtOH CHO -NO, CH,0 4-Methoxyacetophenone 4-Nitrobenzaldehyde (2E) 144-Methoxyphenyl)-3. (4-nitrophenyl) 2-propen-1-one 2-Chalcones, similar to the compound we will make in lab, are denoted in literature to possess significant binding to B-amyloid (AB) plaques. These plaques have been linked to the development of Alzheimer's Disease. Based on the paper titled "Fluoro-pegylated Chalcones as Positron Emission Tomography Probes for in Vivo Imaging of B-Amyloid Plaques in Alzheimer's Disease" by Ono et al., using ChemDoodle provide the chalcone structure below that possesses the greatest affinity to AB plaques (and thus may be a feasible pharmaceutical agent) based on the tabulated data. Briefly explain why you chose this molecule.

Answer 1