Question

A 41-year-old, 70 kg male patient with severe burns arrives in the ER and needs to...

A 41-year-old, 70 kg male patient with severe burns arrives in the ER and needs to be given IV morphine to treat his pain. The Vd for morphine is 230 L for a 70 kg patient. What IV loading dose do you need to rapidly achieve a therapeutic level of 60 ng /ml to relieve his pain?

a.         3.8 ng

b.         13.8 ng

c.         3.8 μg

d.         13. 8 μg

e.         13.8 mg

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Answer #1

Correct answer is : (e.) 13.8 mg

Explanation

volume of IV = 230 L = 230 x 103 mL

concentration of morphine = 60 ng/mL

mass of morphine = (concentration of morphine) * (volume of IV)

mass of morphine = (60 ng/mL) * (230 x 103 mL)

mass of morphine = 13.8 x 106 ng

mass of morphine = 13.8 x 106 ng * (1 mg / 106 ng)

mass of morphine = 13.8 mg

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