Question

Polarity and Solubility Predictions. MY DRUG : KLONOPIN

Directions: Show your molecule below. Circle or highlight all polar portions of the molecule. Make a reasonable prediction about whether your molecule will be soluble in water or not and explain your reasoning. If your molecule seems to be borderline in polarity, making it difficult to predict solubility, explain your reasoning and the difficulty involved. Find a source (Merck Index, PDR, etc.) that discusses the water-solubility of your drug. Compare your predictions with the information you find on the water-solubility of your drug and comment on any discrepancies.

Answer 1

Answer :-

Klonopin is a brand name of drug whose generic name is Clonazepam.( Polar groups are circled by red ink.)

PREDICTION:-

As per the structure - it has many polar groups i.e. 3 nitrogen , 3 oxygen and 1 chloride . But at the same time it has 2 benzene ring and 7 membered heterocyclic ring ,which are non-polar.

So it can be , assumed the it should be slightly soluble in water.

BASED ON MERCK INDEX :-

clonazepam is insoluble in water , slightly soluble in alcohol and very slightly soluble in ether.

It can be compared that , the drug inspite of having polar groups , the nonpolar groups are move effect making it lipid loving.

Desciption:-

Due toh its high lipid solubility it crossses the blood brain barrier and shows its effect on CNS affectively and efficiently.