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Lets say your prevalence is high. You decide to perform this same analysis on a group...

Lets say your prevalence is high. You decide to perform this same analysis on a group of subjects with a much lower prevalence of a disease. Which of the following four measures will be affected by the fact that your study population now has a much lower prevalence of disease? Select all that apply

  1. Sensitivity
  2. Specificity
  3. Positive predictive value
  4. Negative predictive value
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Answer #1

Ans:

Correct options are:

Positive predictive value

Negative predictive value

Prevalence affects the  Positive Predictive Value (PPV) and Negative Predictive Value (NPV). As the prevalence increases, the PPV also increases but the NPV decreases. Also, as the prevalence decreases the PPV decreases while the NPV increases.

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