Question

Lipases are a class of enzymes that catalyze the hydrolysis of lipids containing ester groups. These enzymes are the biological equivalent of an acid catalyst converting the ester into an acid in aqueous condition. Draw the full arrow-pushing mechanism for the hydrolysis of a generic ester under acidic condition. Include all proper arrows for electron flow, formal charges, intermediates and products.

Answer 1

First protonation of Carbonyl oxygen followed by atraat of water to give Tetrahedral intermediate. Deprotonation and removal of alcohol give product.