Question

Machado et. al. refer to the impact of specific and non-specific interactions. By this, they mean that bulk solvent properties such as dielectric constant and refractive index do not tell a very complete story of the stabilizing effects that solvents have. Characterizing a solvent by its dipole moment in this context also has its shortcomings. In contrast, to get a full picture of solute-solvent interactions, one must differentiate between the specific

interactions that exist. With this in mind, what do you consider the major shortcomings associated with describing a solvent’s polarity using the dielectric constant? Using the dipole moment?

4. Christian Reichardt has proposed using ET(30) as an experimental measure of solvent polarity that is superior to measurements of the dipole moment and/or dielectric constant. What do you think of this idea?

Answer 1

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