Do small changes in permeability produce small changes in Vm for both Na+ and K+? Are...
Homework Answers
Concepts
Formula Used: Goldman equation
where PK, PNa and PCl= permeabilities for K+, Na+ and Cl- ions, respectively. Vm is the membrane potential. z is the valence the ion. Since, Cl- ion is not included, hence,
Answer:
Increasing permeability of a membrane for ion shifts the membrane potential towards the equilibrium potential for that type of ion.
Now, we can assume Goldman equation to be a logarithmic equation of type y = log(x)
Differentiating this equation we get,
Assume 
to be Vm and 
to be the term containing permeability. This equation indicates
that the magnitude of
depends on the magnitude of
and x.
- if
, increase in 
is much more than the increase in 
. - if
increase in
is less in comparison to increase in
.
, increase in 
increase in Living membranes are highly permeable to potassium but have limited permeability for sodium.
Hence, even a small change (increase) in the permeability of potassium shifts the Vm value towards the Eion (equilibrium potential) of potassium.
However, a large amount of change (increase) in the permeability of sodium is required to shift the Vm value to the Eion of sodium ion. This is because of the permeability of sodium ions. It is very less for biological membranes.
Add Answer to:
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Consider this cell. Use this information to answer the following questions. IN OUT Relative Permeability [Na+]mM 0.05 10 100 [K+]mM 1.0 [CI]mM 0.05 [Ca++]mM 0.001 0.00001 [A-]mM 105
(OHow does the relative permeability of the membrane to Na and K throughout the course of the action potential change compared with that at the resting membrane potential? From the following, select the statement(s) which are CORRECT: Select one or more: a. The number of potassium voltage-gated channels that open determine the amplitude of the action potential b. During the peak of an action potential, there is a 500x increase in the concentration of Na+ that move into the cell....
ssignment: Ch 4,5 ng Activity Figure 5.23 0 150 mM K+ No ion permeability = no membrane potential e 0 + + 0 The first Kion leaves the cell 0 + Concentration gradient K+ leak channel 5 mM K 0 + + + -1 Equilibrium potential of -90 mV + Electrical gradient
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Changes in K+ ion concentrations are often dangerous. Simply doubling the concentration of K+ in the extracellular fluid, can lead to death. Which of the following choices correctly explains why deviations in K+ concentrations can be lethal? Select one: a. Excess K+ in the ECF diminishes the electrochemical gradient for K+ to leak out of the cell. As fewerk leave the cell, the resting membrane potential become more positive and is more likely to depolarize. b. Excess K+ in the...
choices for A: Na+/K+ pumps, voltage gated K+ channels,
voltage gated Ca+ channels, voltage gated Na+ channels
choices for B: bidirectionally, unidirectionally
choices for C: Na+/K+ pumps, voltage gated K+ channels,
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choices for D: Na+/K+ pumps, voltage gated K+ channels,
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