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If a neuron has GABAA receptors postsynaptically, how will a sudden administration of ethanol affect that...

If a neuron has GABAA receptors postsynaptically, how will a sudden administration of ethanol affect that neuron? Explain briefly and include the following 4 kinds of effects: the likely action at the GABAA receptors (increased or decreased activity?); ion flow (Cl- or Na+ influx or efflux?); IPSPs or EPSPs; and hyperpolarization or depolarization of the neuron membrane.

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The GABAA receptors are responsible for rapid neuronal transmission in the mammalian CNS. They occur in the postsynaptic membrane. The effects of ethanol on proteins in the CNS are complex suggests that it appears that ligand-gated ion channels and voltage-gated calcium channels are important targets for this drug because their function, type and numbers are altered by short- and long-term exposure to ethanol. It mimics GABA's effect in the brain thereby binding to GABA receptors and inhibiting neuronal signalling, major excitatory neurotransmitter, glutamate, particularly at the N-methyl-d-aspartate (NMDA) glutamate receptor.

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