There are two types of drugs targeting hypoxic cells: hypoxic radiosensitizers and hypoxic cytotoxins. Discuss the...
There are two types of drugs targeting hypoxic cells: hypoxic radiosensitizers and hypoxic cytotoxins. Discuss the molecular mechanisms of action of these types of drugs. What is the major difference?
Homework Answers
Hypoxic Radiosensitizer is uses in the treatment of tumor. Radiosensitizer is an agent that makes tumor cells more sensitive to radiation therapy. Its mechanism of action is that, the radiation is used, causing the cells in S-phase to disrepair DNA damage.
Hypoxic Cytotoxins are agents that can sensitize a solid tumor to radiotherapy or to chemotherapy by killing, rather than sensitizing the resistant hypoxic cells.
Hypoxic Cytotoxins are also known as Bioreductive drugs.
The main difference between Hypoxic Radiosensitizer and Hypoxic Cytotoxins is that, the hypoxic radiosensitizer uses radiation to sensitize the tumor cells whereas the hypoxic cytotoxins works by killing the resistant cells.
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There are two types of drugs targeting hypoxic cells: hypoxic
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