In a typical human cell at 37°C, the concentration of ATP is 3.5E-3M, ADP = 4.5E-3M,...
In a typical human cell at 37°C, the concentration of ATP is 3.5E-3M, ADP = 4.5E-3M, and Pi (HPO4 2-) = 7.6E-3M. Remember that living cells are NOT at equilibrium.
ATP + H2O -> ADP + Pi
a. What is the actual free energy change (ΔG') for ATP hydrolysis under these physiological conditions? ΔG0' for ATP hydrolysis = -30kJ/mol
b. In which direction will the reaction proceed under these conditions? Why?
Homework Answers
b) reaction proceeds in
forward direction as ∆G is negativeAdd Answer to:
In a typical human cell at 37°C, the concentration of ATP is
3.5E-3M, ADP = 4.5E-3M,...
Consider the hydrolysis of ATP: ATP(aq) + H2O(l) → ADP(aq) + Pi(aq). This reaction has ΔH°=...
Consider the hydrolysis of ATP: ATP(aq) + H2O(l) → ADP(aq) + Pi(aq). This reaction has ΔH°= −24.3 kJ/mol and ΔS°= +21.6 J/mol-K. The actual concentrations of ATP, ADP, and Pi are not 1 M in a biological cell. How much energy can the conversion of ATP to ADP supply when it occurs at physiological conditions in E. coli where the temperature is 37°C and the approximate concentrations are ATP = 11.2 mM, ADP = 1.52 mM, Pi = 20.0 mM?...
Question 11 1 pts Consider the hydrolysis of ATP: ATP(aq) + H2O(1) - ADP(aq) + P(aq). This reaction has AH°= -24.3...
Question 11 1 pts Consider the hydrolysis of ATP: ATP(aq) + H2O(1) - ADP(aq) + P(aq). This reaction has AH°= -24.3 kJ/mol and AS - +21.6 J/mol-K. The actual concentrations of ATP, ADP, and Pi are not 1 Min a biological cell. How much energy can the conversion of ATP to ADP supply when it occurs at physiological conditions in E.coli where the temperature is 37°C and the approximate concentrations are ATP - 14.8 mM, ADP - 3.65 MM, P,...
The reaction catalysed by pyruvate kinase is: K'eg 3.63 x 105 Phosphoenolpyruvate + ADP -> pyruvate ATP a) Calculate the AG°" for this reaction. Show your working. 3 marks b) The hydrolysi...
The reaction catalysed by pyruvate kinase is: K'eg 3.63 x 105 Phosphoenolpyruvate + ADP -> pyruvate ATP a) Calculate the AG°" for this reaction. Show your working. 3 marks b) The hydrolysis of ATP has following equation: ATP+H20ADP P AG-30.5 kJ/mol Calculate the AG" for the following reaction: Phosphoenolpyruvate -> pyruvate Pi Show your working. 2 marks c) At 37 °C, the steady-state concentrations of phosphoenolpyruvate, ATP, and ADP have been measured to be 23 μΜ, 1.85 mM and 140...
1. Animal cells have a Na,K pump that couples the energy of ATP hydrolysis to transport 3 Na ions out of the cell and 2 K ions into the cell. Inside astrocytes, the concentration of Na is 20 mM and th...
1. Animal cells have a Na,K pump that couples the energy of ATP hydrolysis to transport 3 Na ions out of the cell and 2 K ions into the cell. Inside astrocytes, the concentration of Na is 20 mM and the concentration of K is 130 mM. The extracellular concentrations of Na and K are 145 mM and 5 mM, respectively. Calculate the energy required for the transport of Na and K , with this stoichiometry; assume that the cell...
The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell...
The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell under the use of ATP. Under normal circumstances, the concentration of K+ inside the cell is 140 mm, while the [K] outside of the cell is 6 mM. The concentration of Nat inside the cell is 16 mM, while the [Na] outside the cell is 145 mm. The membranpotential is -0.07 V The temperature is 37°C/310,15K c) Calculate how much energy (kJ/mol it takes...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate (Pi) (a) Is the reaction favorable under standard biochemical conditions? Explain your answer. (b) What is the equilibrium constant (K) of this reaction at 25°C? In cells the direct hydrolysis of PEP rarely occurs. Rather, the hydrolysis of PEP and the reverse hydrolysis of ATP are coupled (c) w rite out the coupled reaction and determine its ΔG at 25°C The hydrolysis of ATP...
1. In a cell, a thermodynamically unfavorable process can occur if the process is coupled to...
1. In a cell, a thermodynamically unfavorable process can occur if the process is coupled to a thermodynamically favorable process. the process is thermodynamically favorable outside the cell. an enzyme gives energy to the reacting substances. the cell as a whole is close to equilibrium. 2. In an active transport protein, ATP hydrolysis creates a channel through the membrane. ATP uses the protein to move across the membrane. ATP hydrolysis causes the protein to change shape. ATP carries a substance...
21.) Consider the standard free energies shown below(T =37 °C, R-8.3 145 J/mole K) : UDP-Glucuronate...
21.) Consider the standard free energies shown below(T =37 °C, R-8.3 145 J/mole K) : UDP-Glucuronate + H20 UTP+ H2O M+ Pi+ PPE+ H202Pi AG =-36.9 kJ/mol 39 AG =-32.5 kJ/mol -32.5 AG-33.6 kJ/mol 1-Phosphoglucuronate+UMP+ (A) (3 pts) Calcul ate AG & Keg for the following reaction. 1-Phosphoglucuronate + UTP + H2O UDP-Glucuronate + 2Pi (B) (2 pts) Which of the following statements best describe this reaction? (A)The reaction is irreversible under standard conditions. (B) The reaction is reversible under...
Question 1 - Linked Reactions (10 marks) The reaction catalysed by pyruvate kinase is: Phosphoenolpyruvate+ ADPpyruvateATP Keg 3.63 x 105 a) Calculate the AG" for this reaction. Show your work...
Question 1 - Linked Reactions (10 marks) The reaction catalysed by pyruvate kinase is: Phosphoenolpyruvate+ ADPpyruvateATP Keg 3.63 x 105 a) Calculate the AG" for this reaction. Show your working. 3 marks b) The hydrolysis of ATP has following equation: AG 30.5 kJ/mol Calculate the AG" for the following reaction: Phosphoenolpyruvate pyruvateP Show your working. 2 marks c) At 37 °C, the steady-state concentrations of phosphoenolpyruvate, ATP, and ADP have been measured to be 23 HM, 1.85 mM and 140...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
Question 11 1 pts Consider the hydrolysis of ATP: ATP(aq) + H2O(1) - ADP(aq) + P(aq). This reaction has AH°= -24.3 kJ/mol and AS - +21.6 J/mol-K. The actual concentrations of ATP, ADP, and Pi are not 1 Min a biological cell. How much energy can the conversion of ATP to ADP supply when it occurs at physiological conditions in E.coli where the temperature is 37°C and the approximate concentrations are ATP - 14.8 mM, ADP - 3.65 MM, P,...
The reaction catalysed by pyruvate kinase is: K'eg 3.63 x 105 Phosphoenolpyruvate + ADP -> pyruvate ATP a) Calculate the AG°" for this reaction. Show your working. 3 marks b) The hydrolysis of ATP has following equation: ATP+H20ADP P AG-30.5 kJ/mol Calculate the AG" for the following reaction: Phosphoenolpyruvate -> pyruvate Pi Show your working. 2 marks c) At 37 °C, the steady-state concentrations of phosphoenolpyruvate, ATP, and ADP have been measured to be 23 μΜ, 1.85 mM and 140...
The Na+/K+ pump transports 2 K+ into the cell and 3 Nat out of the cell under the use of ATP. Under normal circumstances, the concentration of K+ inside the cell is 140 mm, while the [K] outside of the cell is 6 mM. The concentration of Nat inside the cell is 16 mM, while the [Na] outside the cell is 145 mm. The membranpotential is -0.07 V The temperature is 37°C/310,15K c) Calculate how much energy (kJ/mol it takes...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate (Pi) (a) Is the reaction favorable under standard biochemical conditions? Explain your answer. (b) What is the equilibrium constant (K) of this reaction at 25°C? In cells the direct hydrolysis of PEP rarely occurs. Rather, the hydrolysis of PEP and the reverse hydrolysis of ATP are coupled (c) w rite out the coupled reaction and determine its ΔG at 25°C The hydrolysis of ATP...
21.) Consider the standard free energies shown below(T =37 °C, R-8.3 145 J/mole K) : UDP-Glucuronate + H20 UTP+ H2O M+ Pi+ PPE+ H202Pi AG =-36.9 kJ/mol 39 AG =-32.5 kJ/mol -32.5 AG-33.6 kJ/mol 1-Phosphoglucuronate+UMP+ (A) (3 pts) Calcul ate AG & Keg for the following reaction. 1-Phosphoglucuronate + UTP + H2O UDP-Glucuronate + 2Pi (B) (2 pts) Which of the following statements best describe this reaction? (A)The reaction is irreversible under standard conditions. (B) The reaction is reversible under...
Question 1 - Linked Reactions (10 marks) The reaction catalysed by pyruvate kinase is: Phosphoenolpyruvate+ ADPpyruvateATP Keg 3.63 x 105 a) Calculate the AG" for this reaction. Show your working. 3 marks b) The hydrolysis of ATP has following equation: AG 30.5 kJ/mol Calculate the AG" for the following reaction: Phosphoenolpyruvate pyruvateP Show your working. 2 marks c) At 37 °C, the steady-state concentrations of phosphoenolpyruvate, ATP, and ADP have been measured to be 23 HM, 1.85 mM and 140...
1. According to the paper, what does lactate dehydrogenase
(LDH) do and what does it allow to happen within the myofiber? (5
points)
2. According to the paper, what is the major disadvantage of
relying on glycolysis during high-intensity exercise? (5
points)
3. Using Figure 1 in the paper, briefly describe the different
sources of ATP production at 50% versus 90% AND explain whether you
believe this depiction of ATP production applies to a Type IIX
myofiber in a human....
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