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If the solubility of caffeine in water is 22 mg/mL at 20˚C and 66 mg/mL at...

If the solubility of caffeine in water is 22 mg/mL at 20˚C and 66 mg/mL at 100˚C, and its solubility in dichloromethane is 140 mg/mL at 20˚C, calculate the partition coefficient for a water/dichloromethane mixture.

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Answer #1

The partition coefficient at 20 ° C is calculated:

K = Concentration in water / Concentration in dichloromethane = 22 mg / mL / 140 mg / mL = 0.16

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