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What kind(s) of chemical bond(s) is(are) involved between a DNA molecule and a histone protein?  What kind(s)...

What kind(s) of chemical bond(s) is(are) involved between a DNA molecule and a histone protein?  What kind(s) of chemical bond(s) is(are) involve when a substrate molecule interacts with an enzyme?

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The double helix of deoxyribonucleic acid or DNA contains nucleotides. The nucleotides contain a phosphate group. The phosphate group is anionic in nature. Hence, it is negatively charged. Due to the presence of a large number of the phosphate group, DNA molecule gets negatively charged. On the other hand, Histone protein contains positively charged amino acids, lysine, and arginine. Due to the presence of two opposite charges, a strong electrostatic interaction occurs between DNA and Histone protein.

The enzymes contain proteins. The globular proteins present in enzymes contains various amino acids. The main interaction between substrate and active site of the protein is controlled by the interaction between amino acid residue present in protein and substrate. The hydrophobic interaction, weak electrostatic interaction and hydrogen bonding interactions are mainly involved when a substrate molecule interacts with an enzyme.

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