Question

1. Individuals that ingested MPTP, produced during the attempted synthesis of MPPP an analog of prodine, developed symptoms indicative of Parkinson's disease. Something went wrong with the synthesis. Describe the synthesis of MPPP, and explain what went wrong leading to the formation of MPTP
2. A number of Non-Pharmaceutical Fentanyl (NPF) derivatives have appeared on the illicit drug scene in the last few years, including Carfentanyl, Acrylfentanyl, Methoxyacetylfentanyl, and Cyclopropyl fentanyl. Research one of these and summarize its synthesis

Answer 1

AS PER THE CHEGG RULES I AM ABLE TO ANSWER FIRST ONE ONLY

ANSWER:

EXPLANATION:

What what went wrong leading to the formation of MPTP:

• MPTP was formed during the reaction with the phenyl grignard, in the acylation step.
• MPTP could also get formed if the intermediate alcohol was exposed to strongly acidic conditions.
• If the sample is not purified adequately, then due to its ease of formation MPTP could contaminate the MPPP product.

• 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) could get generated accidently as a major contaminant byproduct during the synthesis of Desmethylprodine (MPPP)
• MPTP inhibits tyrosine hydroxylation which is required for the formation of dopamine.
• Due to the lowering of dopamine levels, it can cause acute Parkinson's disease.