Why is the OH group of salicylic acid actively involved compared to COOH group during formation...
Why is the OH group of salicylic acid actively involved compared to COOH group during formation of aspirin?
Homework Answers
The phenolic OH group is more nucleophilic compare to acidic OH group (less nucleophilic) that is why acetylation takes at phenolic oxygen.In -COOH group the charge is distributed over two oxygens whereas in phenol the charge resides on oxygen
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Why is the OH group of salicylic acid actively
involved compared to COOH group during formation...
Why is –OH group of salicylic acid actively involved compared to –COOH group during formation of...
Why is –OH group of salicylic acid actively involved compared to –COOH group during formation of aspirin?
When old aspirin breaks down salicylic acid is formed. What functional group does salicylic acid have...
When old aspirin breaks down salicylic acid is formed. What functional group does salicylic acid have that aspirin does not? -OH Opera Olaondo acid catalyst + some stuff -©—OH 0-C-CH3 + CH3—C—OH acetic acid OH aspirin Salicylic acid
4. The base hydrolysis reaction for the conjugate base of salicylic acid (C6H (OH)(COOH)) is A:...
4. The base hydrolysis reaction for the conjugate base of salicylic acid (C6H (OH)(COOH)) is A: CHA(OH)(COOH) + H2O <==> CHA(OH)(COO) + H20* B: CH(OH)(COOH) + H2O <==> C6H4(OH)(COO) + OH C: CHA(OH)(COO) + H2O <==> C6H4(OH)(COOH) + OH Ky for this reaction is Check two (2) boxes. 0 O A (blank 1) B (blank 1) C (blank 1) 11.03 (blank 2) 1.07x10^-3 (blank 2) 9.33x10^-12 (blank 2) 0 0
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why...
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why is it better to perform acetylation with acetic anhydride rather than using a Fischer esterification with acetic acid? 2. Draw a complete arrow-pushing mechanism for the reaction. 3. When an old sample of aspirin is left in moist conditions, it will begin to smell like vinegar. Draw a reaction scheme and briefly explain what happened.
please explain why percentage of salicylic acid impurity is low and underline good solvent for aspirin ! the given is pure aspirin compared to mine which is impure so 5% ! Why is that Percentage...
please explain why percentage of salicylic acid impurity is
low and underline good solvent for aspirin !
the
given is pure aspirin compared to mine which is impure so 5% ! Why
is that
Percentage of salicylic acid impurity 5 Underline those characteristics listed which would be likely to be present in a good solvent for aspirin hydrogen bonding organic aliphatic polar inorganic aromatic nonpolar nonhydrogen bonding
Percentage of salicylic acid impurity 5
Underline those characteristics listed which would be...
Acetylsalicylic acid (aspirin) can be synthesized from salicylic acid and acetic acid in an acidic solution....
Acetylsalicylic acid (aspirin) can be synthesized from salicylic acid and acetic acid in an acidic solution. COOH COOH Сн,соон на + H20 H HC. O-H salicylic acid acetylsalicylic acid (aspirin) We were unable to transcribe this image
3. 0.69g of salicylic acid was reacted with 0.6g acetic anhydride in the presence of concentrated phosphoric acid...
3. 0.69g of salicylic acid was reacted with 0.6g acetic anhydride in the presence of concentrated phosphoric acid to yield 0.80g of acetyl salicylic acid (see below). Determine the limiting reagent and percent yield. C-CH OH COOH CH, COOH CHC Salicylic acid MW 138.12. mp 159C Acetic anhydride Acetylsalicylic acid M W 102.09. bp 140CMW 180.15. mp 128-1370 4. How do you account for the smell of vinegar when an old bottle of aspirin opened?
Propose a structure for the polymer formed by intermolecular reaction of salicylic acid during the synthesis of aspirin. Which is the stronger acid, aspirin or salicylic acid?
Propose a structure for the polymer formed by intermolecular reaction of salicylic acid during the synthesis of aspirin. Which is the stronger acid, aspirin or salicylic acid?
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride,...
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride, phosphoric acid acts as a catalyst by O cleaving an acetyl group from acetic anhydride via protonation of the bridging oxygen O neutralizing the hydroxide ion side product protonating the carbonyl oxygen in the acetic anhydride protonating the phenolic oxygen of salicylic acid Question 10 (3 points) What would be the predicted major product from the thermodynamically controlled dehydration of the following material OH
QUESTION 4 Benzoic acid, salicylic acid, and acetyl salicylic acid have a functional group called Phenol...
QUESTION 4 Benzoic acid, salicylic acid, and acetyl salicylic acid have a functional group called Phenol and salicylic acid have a functional group called Acetyl salicylic acid is the only compound with an QUESTION 5 If 1.57 g of salicylic acid (MW = 138.121 g/mol) and 6.9 mL of acetic anhydride (MW = 102.09 g/mol; d = 1.08 g/mL) was used to synthesize aspirin (MW = 180.2 g/mol). How many mols of salicylic acid were used? (Answer to the ten...
When old aspirin breaks down salicylic acid is formed. What functional group does salicylic acid have that aspirin does not? -OH Opera Olaondo acid catalyst + some stuff -©—OH 0-C-CH3 + CH3—C—OH acetic acid OH aspirin Salicylic acid
4. The base hydrolysis reaction for the conjugate base of salicylic acid (C6H (OH)(COOH)) is A: CHA(OH)(COOH) + H2O <==> CHA(OH)(COO) + H20* B: CH(OH)(COOH) + H2O <==> C6H4(OH)(COO) + OH C: CHA(OH)(COO) + H2O <==> C6H4(OH)(COOH) + OH Ky for this reaction is Check two (2) boxes. 0 O A (blank 1) B (blank 1) C (blank 1) 11.03 (blank 2) 1.07x10^-3 (blank 2) 9.33x10^-12 (blank 2) 0 0
H3PO4 OH + OH OH salicylic acid acetic anhydride acetic acid acetylsalicylic acid (aspirin) 1. Why is it better to perform acetylation with acetic anhydride rather than using a Fischer esterification with acetic acid? 2. Draw a complete arrow-pushing mechanism for the reaction. 3. When an old sample of aspirin is left in moist conditions, it will begin to smell like vinegar. Draw a reaction scheme and briefly explain what happened.
please explain why percentage of salicylic acid impurity is
low and underline good solvent for aspirin !
the
given is pure aspirin compared to mine which is impure so 5% ! Why
is that
Percentage of salicylic acid impurity 5 Underline those characteristics listed which would be likely to be present in a good solvent for aspirin hydrogen bonding organic aliphatic polar inorganic aromatic nonpolar nonhydrogen bonding
Percentage of salicylic acid impurity 5
Underline those characteristics listed which would be...
Acetylsalicylic acid (aspirin) can be synthesized from salicylic acid and acetic acid in an acidic solution. COOH COOH Сн,соон на + H20 H HC. O-H salicylic acid acetylsalicylic acid (aspirin) We were unable to transcribe this image
3. 0.69g of salicylic acid was reacted with 0.6g acetic anhydride in the presence of concentrated phosphoric acid to yield 0.80g of acetyl salicylic acid (see below). Determine the limiting reagent and percent yield. C-CH OH COOH CH, COOH CHC Salicylic acid MW 138.12. mp 159C Acetic anhydride Acetylsalicylic acid M W 102.09. bp 140CMW 180.15. mp 128-1370 4. How do you account for the smell of vinegar when an old bottle of aspirin opened?
In the mechanism for formation of acetylsalicylic acid via reaction of salicylic acid with acetic anhydride, phosphoric acid acts as a catalyst by O cleaving an acetyl group from acetic anhydride via protonation of the bridging oxygen O neutralizing the hydroxide ion side product protonating the carbonyl oxygen in the acetic anhydride protonating the phenolic oxygen of salicylic acid Question 10 (3 points) What would be the predicted major product from the thermodynamically controlled dehydration of the following material OH
QUESTION 4 Benzoic acid, salicylic acid, and acetyl salicylic acid have a functional group called Phenol and salicylic acid have a functional group called Acetyl salicylic acid is the only compound with an QUESTION 5 If 1.57 g of salicylic acid (MW = 138.121 g/mol) and 6.9 mL of acetic anhydride (MW = 102.09 g/mol; d = 1.08 g/mL) was used to synthesize aspirin (MW = 180.2 g/mol). How many mols of salicylic acid were used? (Answer to the ten...
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