which EAS reaction can be used to make a carbon carbon band in the synthesis of diazepam, a sedative featured in many movies and TV shows as the departed and the big bang theory.
a. Friedel-Crafts Acylation
b. Halogenation
c. Sulfonation
d. Diels- Alder
Correct option: a. Friedel-Crafts Acylation
Among the options, Friedel-Crafts Acylation , halogenation, sulfonation are the examples of Electrophilic aromatic substitution (EAS) reactions. Diels-Alder is an example of pericyclic (cycloaddition) reaction. Thus, the option d can be ruled out first. Halogenation adds halogen to aromatic ring and therefore, it forms C-X bonds (X = F, Cl, Br, I). Sulfonation forms C-S bond. Friedel-Crafts Acylation forms C-C bond.
Hence, the EAS reaction that can be used to make a carbon carbon bond in the synthesis of diazepam is the Friedel-Crafts Acylation reaction.
which EAS reaction can be used to make a carbon carbon band in the synthesis of...