Table 1. % Yield Calculations For The Formation Of Crude IP Salt Samples
|
Reagents |
IP Salt |
(?)-Ibuprofen |
||||||
|
Notebook Reference |
Description |
Racemic ibuprofen (mass and moles) |
(S)- phenethylamine (mass and moles) |
Theoretical Yield |
Actual mass salt recovered (% yield) |
% Recovery* |
||
|
MP-1 |
Trial 1 IP Salt synthesis |
heated in water at 75C |
30.6 g (0.148 mole) |
17.9 g (19 mL, 14.8 mmole) |
48.5 g |
31.0 g (63.9%) |
63.9% |
|
|
MP-2 |
Trial 2 IP Salt synthesis |
dissolved in 300 mL of 0.5 M KOH at ~75˚C |
30.6 g (0.148 mol) |
19 mL (0.148 mol) |
25 g |
|||
|
MP-3 |
Trial 3 IP Salt synthesis |
MP-1 Procedure was repeated except an excess of (S)-α-phenethylamine (95 mL, ~0.74 mol) was used |
30.6 g (0.148 mol) |
95 mL (0.74 mol) |
2.3 g |
|||
* Assuming a 100% yield for the recovery of (?)-ibuprofen from the IP Salt
Could you please do an example calculation to show me how to get the theoretical yield and % recovery to fill in the last two blank columns? Thank you!
Table 1. % Yield Calculations For The Formation Of Crude IP Salt Samples Reagents IP Salt...