Question

Organic chemistry 352. please help me. thanks!

1 a. The anti-influenza drug Tamiflu inhibits an enzyme involved in the release of new flu viruses from a host cel. When taken, Tamiflu does not become active until it reaches the liver, where it is hydrolyzed by an esterase Esterases are enzymes that catalyze the hydrolysis of esters. Draw the organic products formed when the ester group of tamiflu is hydrolyzed. Assume acidic conditions H/HO) Hio CHCH2) CHO 0 Tamiflu b. A series of steps in the synthesis of Tamilflu involves the transformation below. Outline this series of reactions to carry out the synthesis OCH,CH, 5. CEN Make this Start with this 2. a. Starting with phthalimide, outline the Gabriel synthesis of ethylamine (CH CH2NH2). b. Outline the synthesis of N-ethyl-3-methylpentanamide starting with an acyl chloride and using any other necessary reactants.

Answer 1

eaid and 140 N r ny us

2 0 O kon N.N -1 M1

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