Question

5. In a large mouse study, a drug was administered to one group and compared to a control group. Consider "Normal" biological variation in this study to be 10-20%. The following data were recorded: Measurement Control Group Treatment Group Average Average Number of normal pups Number of heart defects Number of viable offspring Number of corpora lutea Number of implantation sites Average birth weight 10 10 6 13 10 0.8g )a. Based on the above information, what stages or manifestations of abnormal development are induced by the teratogen? b. What stages of development are not affected by the teratogen? ) 6. Match the defect with the appropriate teratogen: tetracycline a) adenocarcinoma b) amelia c) microophalmia d) poor enamel development (teeth) e) hydrocephalus diethylstilbestrol vitamin A thalidomide

Answer 1

Question no:3

1. Vitamin A- hydrocephalous, microphthalmia
2. Thalidomide- Amelia
3. Tetracycline- poor enamel development(teeth)
4. Diethylstilbestrol- adenocarcinoma

Question no:1

1. At stage of 34 days- transposition of great vessels
2. At the stage of 6weeks- ventricular septal defect
3. At the stage of 9-10 months- patent ductus arteriosus

Question no:2

1. The embryo stage is well protected in the uterus till structural development.
2. Fetal period is less vulnerable to teratogen