Question

Respiratory Case An 18-year-old man, VB, presents with a history of recurrent episodes of wheeze after walking 200 metres. VB has recently started to go to a gym and his episodes of wheeze have worsened. He goes to see his GP. He can talk in sentences but his respiratory rate is increased. His peak flow is 420 L/min which is 80% of predicted result. A diagnosis of mild asthma is made. He is started on salbutamol metered dose inhaler (MDI) two puffs when required and beclometasone (Qvar) 50 micrograms twice daily. 1. What is asthma? 2. What are the risk factors for developing asthma? 3. What is the pharmacology of beta2-agonists and inhaled corticosteroids? 4. What are the side-effects of beta2-agonists? 5. What formulations of salbutamol and inhaled corticosteroids are available and what are the advantages and disadvantages? 6. Describe how to use an MDI.

Answer 1

1. What is asthma?

Answer :- Asthma is a long-term disease of the lungs. Many Doctor doctor call it a chronic respiratory disease

2. What are the risk factors for developing asthma?

Answer :-

• Family History
• Obesity
• Occupational exposure
• Allergies.
• Viral respiratory infection.
• Smoking
• Air Pollution.

3. What is the pharmacology of beta2-agonists and inhaled corticosteroids?

Answer - ICS/LABA items are economically accessible for asthma upkeep treatment (fluticasone propionate/formoterol fumarate, fluticasone propionate/salmeterol xinafoate, budesonide/formoterol fumarate and beclometasone dipropionate/formoterol fumarate), and different mixes are probably going to be created throughout the following couple of years (for example mometasone/formoterol fumarate, fluticasone furoate/vilanterol, mometasone/indacaterol)., pharmacological information show that there might be sure points of interest to utilizing one ICS or LABA over another in light of the particula pharmacokinetic profiles related with specific medicines. This survey article condenses the pharmacological attributes he different ICSs and LABAs accessible for the treatment of including the potential for ICS and LABA cooperative energy, and gives an understanding into the basis for the advancement of the most recent ICS/LABA mix endorsed for asthma upkeep treatment.

4. What are the side-effects of beta2-agonists?

Answer :-

• Trembling, In the hands.
• Nervous tension.
• Headaches.
• suddenly noticeable heartbeats .
• Muscle cramps.

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