Question

Part I:

A 10-year-old boy is admitted to the emergency department with a badly swollen knee and hematuria. He has had frequent severe bleeding since birth.

PT:                       12.2 sec

APTT:                             98.2 sec

PLT:                     389 ´10⁹/L            

Bleeding time:     4 min

The results of the proposed additional studies were as follows:

Factor VIII assay:           5%

Factor IX assay:         110%

1.         Interpret the coagulation screening tests and additional tests.

            

2.         Based on all the data provided, what condition is most likely?

            

3.         What information is most diagnostic?

4.         What conditions are ruled out by the normal bleeding time?

            

5.         Why are factor VIII and IX assays run?

Answer 1

1.interpretation:

PT: Normal

aPTT: Prolong/ incest

PLT: Normal

Bleeding time : normal

Factor 9: normally

Factor 8: reduced

2. Which condition:

Hemophilia A

3. prolong aptt and reduced factor VIII suggest hemophilia A.

4. Hemophilia won't affect bleeding time, only it affect clotting time.

5. Factor VIII for hemophilia A

Factor IX for hemophilia B.