Picot question: women in menopause on hormone replacement therapy to prevent osteoporosis VERSUS women on non hormone therapy replacement
Time of therapy 1to 3years
Discuss positve and negatif outcome, limited to Osteoporosis prevention.
Discusses main ideas related to topic clearly, utilize the literature to support position
show your ref.
Estradiol (E2) and progesterone (P4) collaborate to helps in bone remodelling on resorption (E2) and formation (P4).Progesterone stimulates the osteoblast and its differentiation.From the menarche onwards and onset of ovulation estrogen is secreted from a temporary gland formed within the ovary after ovulation is called corpus luteum.Progesterone is produced by the ovaries,placenta and adrenal glands.
The estrogen and progesterone work together in women to maintain a womans normal physiology The estrogen plays a important role in maintaining bones normal biology and helps from osteoporosis prevention.In the estrogen the estradiol E2 facilitates the vitamin D related intestinal calcium absorption nad the progesterone helps in osteoblast maturation and differentiation.
After menopause there is a cessation of ovulation and results in oestrogen and progesterone deficiency results in chance of developing osteoporosis.
When once a women reach the menopause oestrogen levels drops,that results in reduced bone strength in later life.
Hormone Replacement Therapy (HRT) is a drug treatment,that is particularly estrogen,which our body produce naturally during the fertilization period and helps to keep the bones strong.Along with estrogen,HRT may also contain a another vital hormone for the females called progesterone.In the HRT therapy we are administering Progestogen is a synthetic version of a hormone called progesterone that helps in osteoblasts maturation and differentiation.
Positive outcomes of HRT :
*facilitates the vitamin D-related intestinal calcium absorption
*suppression of bone resorption
*it improves the bone mineral density
*prevents osteoporotic related fractures
Negative outcomesof HRT:
*The HRT therapy combine with oestrogen and progesterone is are effective for osteoporosis,but there may be a chance of breat cancer.
*Risk for thromboembolism
*Dementia
*Nausea
*leg cramps
*vaginal bleeding
*swelling in other parts of body
Picot question: women in menopause on hormone replacement therapy to prevent osteoporosis VERSUS women on non hormone th...
Hormone replacement therapy (HRT) for women undergoing menopause, either natural or surgical, is the subject of a number of studies and debate. On one hand, it relieves many of the unpleasant symptoms of menopause and reduces the risk of coronary artery disease and osteoporosis in post-menopausal women- both major courses of morbidity and mortality. On the other hand, it may increase the risk of endometrial cancer or breast cancer in some women. Review the current literature on the risks and...