Question

Table 3: Dopamine Agonist Treatment Status and Impulse Control Disorder (ICD) Frequencies One or More Current No Current ICDs ICDs 978 No dopamine agonist Dopamine agonist 72 348 1692 Source: Weintraub, D., Koester, J., Potenza, M. N., Siderowf, A. D., Stacy, M., Voon, V., & Lang, A. E. (2010) Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Archives of neurology, 67(5), 589-595. 4.7 marks] Weintraub et al (2010) conducted a cross-sectional study to investigate the poten tial association between dopamine-replacement therapies for Parkinson disease and impulse control disorders (ICDs). Consider the exposure to be treatment with a dopamine agonist drug and the outcome to be the presence of at least one of four ICDs (gambling, compulsive sexual behaviour, compulsive buying, and binge-eating disorder). The data in the Table 3 come from Table 2 of the original manuscript. a) What is the prevalence of having one or more impulse-control disorders among the study participants? b) Calculate the prevnlence of the outcome in the exposed and unexposed group (c) Without doing any formal statistical tests, do you think there is an association between the exposure and outcome? Write 1-2 sentences describing the results of this study. d) Describe how you would run a cohort study to assess the same potential association.

Answer 1

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