Question

In each reaction box, place the best reagent and conditions from the list below. If you reduce the alkyne in step 3, you would need six steps overall to produce the final carboxylic acid.

Answer 1

Concepts and reason

• One or more substances that react together to form a product is called a chemical reaction. Most chemical reactions take place with the help of reagents.

• Reagents are the substances used to transform one form of a substance to another.

• The reaction undergoes a series of steps like deprotonation of an alkyne, substitution, and hydrogenation reactions to attain a final product.

Fundamentals

The reagents play a vital role in all the reactions. Each reagent plays a different role in the chemical reaction.

Deprotonation of alkynes:

An alkyne undergoes deprotonation with the help of the reagent sodium amide. Acetylide ion forms when sodium amide reacts with an alkyne. Acetylide ion acts as a good nucleophile which undergoes a substitution reaction with alkyl halides and forms a new carbon chain.

Substitution:

The nucleophilic substitution reaction takes place when the nucleophile undergoes reaction with alkyl halides.

Hydroboration of alkenes:

Borane in THF is a reagent which is used for the hydroboration of alkenes to give alkyl borane (organoboron) which is treated with forms alcohol.

Oxidation of aldehydes:

Aldehydes are oxidized to carboxylic acids using a suitable reagent such as, .

The reaction is given below:

Ans:

The best reagent and conditions for the given reaction: