Question

Grignard and organolithium reagents are powerful bases. Because of this, they cannot be used as

nucleophiles on compounds which contain acidic hydrogens. If they are use, they will act as a base and

deprotonate the acidic hydrogen rather than act as a nucleophile and attack the carbonyl. A partial list of

functional groups which cannot be used are: alcohols, amides, 1o amines, 2o amines, carboxylic acids, and

terminal alkynes.

Determine the product of a reaction in which one of the reactant contains both a hydroxyl group and a

carbonyl group.

Answer 1

write a 9 reaction with st og that has both a hydroxyl group and group la carboni le is also this carbon 161th oH possi tive charged this carbon is possitive charged 1oxy de acts as to bond with carbonile and partial po OH # Parere

With OH +A - alpha protons It takes alcohol because is more acid than - protons

reacts by acid-base to give Mg Belt with a react to give live li 8(+) a ith a carboxylic acid like u To Mg Br reacts to form io Mobil +

eacts by an acid base mechanism