Question

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= Objective knowledge Check Question 8 Black Forest Biologicals, a biotech startup, has a promising Alzheimer's drug candidate Compound SLT-88 entering Phase I trials this year. SLT-88 is the only product formed by the reaction of two precursor compounds A and B, both of which are quite expensive. The chief medicinal chemist of Black Forest is trying out different reaction conditions to minimize the cost of manufacturing SLT-88 In the table below are listed the initial and final amounts of A and B used under two different trial conditions, and also the actual amount of SLT-88 recovered in each case. Complete the table by calculating the theoretical yield of SLT-88 and the percent yield of SLT-88. Round your amounts to the nearest milligram and your percentages to the nearest whole percent amount of A amount of B yield of SLT-88 Trial initial final initial final theoretical actual 100 mg 0 mg 600 mg 306 mg 1 327. mg x 5 ? 850 mg 0 mg 600 mg 414.mg 663 mg

Answer 1

The given reaction is a combination reaction since A and B combine to form a single product SLT-88

A + B -------------> SLT-88

(1) In first case, 100 mg of A is used up in the reaction while (600-306) mg of B which is 294 mg of B is used up to form 327 mg of SLT-88

Since SLT-88 is the only product, theoretically mass of A + B consumed in the reaction should be equal to mass of SLT-88

i.e 394 mg of SLT-88 should be formed theoretically from 100 mg of A and 294 mg of B.

Thus,

Yield % = 327*100/394 = 82.99%

Thus in first case,  

Theoretical yield of SLT-88 = 394 mg

Yield obtained = 82.99%

2) In the second case,

850 mg of A reacts with (600 - 414) mg of B, which is 186 mg of B to give 663 mg of SLT-88.

Expected theoretical yield of SLT-88 = 850 + 186 mg = 1036 mg

Yield % = 663*100/1036 = 63.99%