Question

Explain why sickle hemoglobin (Hb S) molecules would be likely to clump together whereas hemoglobin (Hb A) molecules do not?

I want a biochemistry-related explanation.

Detailed explanation = thumbs up

Answer 1

Answer:

• Here the change in only one amino corrosive of a protein changes the whole science of the protein consequently prompting an ailment.
• Sickle cell sickliness is a case of a harm brought about by an adjustment in single base of DNA.
• The area of DNA that codes for \beta-subunit of hemoglobin is adjusted which sign for fuse of valine rather than glutamic corrosive.
• Glutamic corrosive is polar though valine is non-polar and this change is sufficient to change the state of whole atom.
• Since Hb S atoms contain non-polar valine, its dissolvability in red platelets is decreased, making it hasten in red platelets.
• Hb S particles as opposed to being pulled in to hydrophillic condition of the cell, communicate with one another offering ascend to polymer.
• Giving oxygen treatment couldn't be compelling treatment over the long haul since this can't change the sickle molded cell.
• The cell which is stuck coagulated shape can't scrape to oxygen, regardless of how extraordinary the measure of oxygen is available.
• Potential medications for this malady might be quality treatment or some medication which diminishes the formation of Hb S atoms.