Question

сH H3C H CHз OH N H,с Lopinavir A. Consider the portion of the molecule designated as "A" (You will notice that the atoms and bonds of this portion of the molecule have been bolded for you.) Which amino acid is this? How do you anticipate that the side chain of this amino acid will contribute to solubility and absorption of this drug? OI NIL Basic Concepts in Medicinal Chemistry 36 Lopinavir is an HIV protease inhibitor. Structurally, this drug is considered a peptidomimetic, in that it resembles (at least in part), the peptide substrate for the protease. In the presence of this agent, HIV protease is unable to cleave the gag-pol polypeptide into its functional proteins during viral assembly and budding. A CH H.C CH3 H OH Lopinavir

Answer 1

valine Gmi a HC

The alkyl part is non polar and hence it makes the molecule to be soluble in non polar or lyophilic tissue as alkyl part is not soluble in water or it is hydrophobic in nature.