Question

FALL 2018 SAN MATEO CAMPUS VOCATIONAL NURSING PROGRAM- Prerequisite Courses F201 Discussion 17 Lecture Discussion 17 Here is a case-study for you to solve. Use what you learned about blood types and Rhesus factor to solve this situation. Two friends, Mike and Jake were returning late at night from a club in the same car. Suddenly, Mike, who was driving, lost control of the car and they crashed into a big tree. Mike ended up with only a few bruises and scratches, but Jake got hurt. Jake had internal bleeding and was taken to a hospital, but he lost a lot of blood and needed a blood transfusion. Mike, feeling responsible for his friend's condition, wanted to donate blood to his friend. Both Mike and Jake had blood type O. So, in the ER, Mike gave 2 pints of blood to Jake. Two weeks later, Jake became anemic. So, Mike, being a good friend, decided to give blood again. However, after the second transfusion, Jake went into an anaphylactic shock (severe immune response) and almost died What, do you think, was the problem here? Your answer should have two parts: 1. Explain, what happened in Jake's body after the first blood transfusion - why did he become anemic so soon after the transfution. (hint: it's not from bleeding) 2. Explain, what happened after the second blood transfusion- why did Jake go into an anaphylactic shock. Use your logical thinking in answering this question. Have fun! question and answer forum. In order to see other responses to these questions, you must first your answer

Answer 1

1. Rh incompatibility is the pathophysiology behind Jake's condition. Jake's blood is Rh negative and Mike's blood is Rh positive . After the first blood transfusion the Rh antigen on the surface of Mike's blood induces formation of anti - Rh antibodies in Jake's blood .

2. Now Jake's blood has developed fully functioning anti - Rh antibodies after first transfusion against Mike's Rh positive blood and it gets attached to the Rh positive red blood cells of Mike and destroys the red blood cells by identifying it as foreign due to presence of Rh protein hence leading to hemolysis ( break down of red blood cells ) causing hemolytic anemia .That's why Jake went to anaphylactic shock .