Question

Please provide a reaction mechanism with a chair state to show how the stereochemistry was achieved. Also, please explain the reasoning/methodology behind the type reaction.

O OH OLI

Answer 1

The product shown above has a methyl group missing.

H. Hr Me (E-isomer) ph ----4 (me and pn are syn to each other) so, me placed equitonal H EL Transition in stoute TH Eto (1) Anti relation. (to show both bonds prominently) OH Et (Product) ме E-isomes in the reactant gives anti product. In making the challs conformation we followed certain things as follows I me - placed equitorial as it is anti to aldeblydic -co and syn to ph-group. Et group placed equitorial as there would have been steric hinder anoe on keeping it anial. 6 chair conformation provides a stable bransient state. Thus such reactions are zimmerman, reactions of aldol formation. are zimmerman - Traxler