Question

1. Unsure whether the hydrolysis would happen at the lactone or the ester.

1. Below is a prodrug that, upon slow reaction with water, releases the drug and another compound. What is the mechanism and what is the structure of the drug and the other compound? Could this other compound be a potential problem in terms of side effects? Is so, then why (show mechanisms)? Sudanto 2. You have discovered a highly potent new drug (X) for treating West Nile virus, but it is soluble only to the extent of 50 mg/L, and it must be administered by injection. The prescribed dose is 300 mg. Design two prodrugs (one at each functional group) to get around this problem. are YOH NH2 O POET

2. Unsure how to make a phosphoramidite more water soluble.

Answer 1

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