What is LogD? a) LogD indicates the distribution of the drug in the cell membranes b)...
What is LogD?
a) LogD indicates the distribution of the drug in the cell
membranes
b) LogD describes the drug as ionic and non-ionic
water solubility of the form
c) LogD is the ionic and non-ionic form of the drug
Partition coefficient between fat and aqueous phases
d) LogD is the same as LogP but declares
partition coefficient at a given pH.
Homework Answers
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What is LogD? a) LogD indicates the distribution of the drug in the cell membranes b)...
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2. The weak base B (Kb = 1.0 * 10-5) equilibrates between water (phase 1) and benzene (phase 2). (a) Define the distribution coefficient, D, for this system. (b) Explain the difference between D and K, the partition coefficient. (c) Calculate D at pH 8.00 if K = 50.0,(d) Will D be greater or less at pH 10 than at pH 8? Explain why.
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(A) Name and (B) draw the head-group of the primary constituent of cell membranes. (C) What is this head group charged at physiological pH? (3 pts) 2) Explain how single nucleotide insertions and deletions could be used to provide evidence that the genetic code is a triplet code. (2 pts)
Toxicology
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