Drug card for Cholinesterase Inhibitors (Anti-Alzheimer’s) memantine (Namenda)
Describe the main effects of cholinesterase inhibitors on structures controlled by the autonomic nervous system and on skeletal muscle, and state the general mechanism by which these effects occur. Compare and contrast the effects of the cholinesterase inhibitors with those of bethanechol, which was described as the most representative muscarinic agonist (see Chapter 14). State the main clinical uses of cholinesterase inhibitors and precautions for and contraindications to their use. Recognize the meaning and importance of the term quaternary when...
Drug card for 2. Miotics, Direct Acting & Cholinesterase Inhibitor pilocarpine (Isopto Carpine)
Drug card for 4. Angiotensin-Converting Enzyme Inhibitors (-prils) benazepril (Lotensin)
State the rationale for using cholinesterase inhibitors to help confirm the diagnosis in multiple sclerosis.
Drug card for Anti-Diabetic Drugs Rapid acting: lispro (Humalog)
State the rationales for administering a cholinesterase inhibitor to a patient who has been intentionally paralyzed (e.g., for surgery) with a neuromuscular blocking drug. State which class of neuromuscular blockers causes effects that can be reversed by the cholinesterase inhibitor. State the other main drug that is given as part of the postoperative reversal procedure and explain when and why it is given. Compare and contrast the cholinergic crisis and the myasthenic crisis in a hypothetical patient with myasthenia gravis,...
35. Name of Drug (Trade and Generic): Aricept (donepezil hydrochloride) Classification and Indication for Use: Normal Dosage: Route of Administration: Side effects: 36. Name of Drug (Trade and Generic): Namenda (memantine HCI ) Classification and Indication for Use: Normal Dosage: Route of Administration: Side effects: 37. Name of Drug (Trade and Generic): Lunesta (eszopiclone) Classification and Indication for Use: Normal Dosage: Route of Administration: Side effects:
1) a) You are working at a pharmaceutical company and the CEO wants to develop a new Alzheimer’s disease drug. Write a brief essay describing what you know about the current development of β-secretase inhibitors and immunotherapy drugs. For each drug included in your answer, give the hypothesis that has been tested, any animal studies performed and the outcomes of human trials. Finish your essay by describing to the CEO your own hypothesis on how the company could invest its...
For question 22, use the following table: Alzheimer’s Disease No Alzheimer’s Disease Total With new drug 10 90 100 With Placebo 60 40 100 Find P(Alzheimer’s disease|New drug). #2 . Use the following information on blood groups for 100 patients to answer questions 24, 25 and 26: (Note: Blood types are mutually exclusive.) Blood type à O A B AB Total 40 30 20 10 If one person is randomly selected, find the probability of getting someone with...
At what point are cholinesterase inhibitors no longer effective in the treatment of Alzheimer disease? When the brain size shrinks and can no longer produce acetylcholinesterase b. When the number of neural transmitters sufficiently decreases c. When the patient's ability to swallow is impaired d. When there are fewer intact neurons available to make acetylcholine 10. What is one of the side effects that is common to many of the antiepileptic drugs? a. Rash b. Increased sodium levels c. Folic...