Question

MEN320 SPR Using the Goldman Equation for calculating the membrane electric potential, calculate the (c) membrane potential for the following solute concentrations. Determine the "Tonic State" of | the cell compared to a typical cell. A154MM NaCl lide 125mM (K+)n, 5mM (K*)ut C0.45% NaClag) solute inpude 5% NaClag) solute inde Galdman Equahen Em- 58 my log/Cx,,bNa b-0.02 0 E5mV 12 m M A 154m M Naci indde The cell -2.0502 c) Em 56ml +lay 15 (.693 Em 58 mv+la /154 7,7 Printed by Woltram Mathematica Student Edtion

Answer 1

Soluton eguation holdman RT In(k7)t F (Kn Em 2 SMMIou ein 125 mM 26.7mV RT F appeoxiat mv. 96.7m EM Inls) EM 2 25 267 mv 53.4m EM 4MV X 1-609 5.92 m 154 Em- 96.7 X 5.42 Ens Em

159 E m =26.7mvLn 7-7 .99 En- 96.7 v m 79 98 v outstde in the cell. 1 54MM Vak