Question

Can you help work me through this problem?

For each of the following reactions or sequences, draw the final major organic product(s) that would form. Include absolute stereochemistry in the answers. Acetic acid BI Z-I -COOME CH2Cl2 2. Me va come more on Br2 2) Medoc- MeOH Br2 MeOH Br2

Answer 1

T De Bojo u - YA Acetic acid A Both form 181 proportion E Br on Chalogue OM Chillz D> Br z umezcoree CZ Copa www Me QC C2 - ano, ma l Cu, lo, CHIR Inuman er, come Cscore form 1,1 proportion Both K B7 L Br major. or minor BY

2 Here methylated center of bromsniu ion is elebo- philic in nature it it is pertially carbócation in introse due to da Croubo contion stabiliy by to hy perconjugation More stable By Br - By minor major 6

e Bromina addition group due to steric i Opposite to the impropyl Rindrence. 4 ① u mejor product because for @ attack the atial bond is blocked so there has no room for back sid attack but for (be it is easier to attack from the back.