Question

5. Given the following molecules, answer the given questions: CH3 TecDE OMe I cot T bernable hyde 1, 3m y toluene H₂c NO2 a WG OME EDO ON NO Beve Quoc cho a. Which structure is the most reactive towards any electrophilic aromatic substitution? b. Which structure is the least reactive towards any electrophilic aromatic substitution? c. Which structure has both EWG and EDG moieties?' A

Answer 1

Reactivity towards electrophilic aromatic substitution depends upon electron density in ring.

Reactivity towards Electrophilic aromatic a x eo density in benzene ring co Substitution -> EDU o => EWA M>H I 4 826 * * +MK+hati atatat strength M= Mesomeric effect 11 = Hyper conjugation H I= Inductive effect +M7-I "{ o-Me +H +1 CH₂J EDG O Me *My-I KTM-3 07, my Ewa EWG & NO2 T-M-I oMe +M>-I Y eDo EDA Testing Europe Eph © eo density order in ring > B>D> A> - Reactivity BYDDAJC @ most peective towards electrophilic aromatic substitution Least Reactive towards electrophilic aromatic Substitution € EWGS EDG group Present in "A" "B" from